
Exercise and cancer: benefits, programs, and prevention
Exercise is increasingly recognized as a critical component of cancer care, offering numerous benefits across all stages of the disease—before, during, and after treatment. Engaging in regular physical activity not only improves your overall health but also enhances your quality of life.
What you'll learn by reading this page:
The role of physical activity in cancer prevention
The science behind cancer and exercise
Physical activity during cancer treatment
Different types of physical activities and how to get started
The role of physical activity for risk reduction
How exercise reduces cancer risk
Regular physical activity is one of the most effective lifestyle choices you can make to reduce your risk of developing cancer. Numerous studies have demonstrated that exercise lowers the risk of several common cancers, including breast, prostate, colon, endometrial, and potentially pancreatic cancer. The American Cancer Society's Guidelines on Nutrition and Physical Activity for Cancer Prevention emphasize that higher levels of physical activity are associated with a lower risk of cancer development.
One of the primary ways exercise reduces cancer risk is by helping to regulate hormones, such as estrogen and insulin, that can contribute to the development of cancer. For example, high levels of estrogen are linked to an increased risk of breast cancer, while insulin resistance is associated with several types of cancer, including colon cancer. Regular exercise helps to normalize these hormone levels, thereby reducing cancer risk.

Moreover, exercise strengthens the immune system, enhancing the body’s ability to detect and destroy cancer cells. The immune system plays a crucial role in surveilling the body for abnormal cells, and a stronger immune response can prevent these cells from developing into full-blown cancers.
Another significant benefit of exercise is its role in weight management. Being overweight or obese is a major risk factor for many types of cancer. Excess body fat can produce hormones and growth factors that stimulate cancer cell growth. In the U.S., it is estimated that obesity contributes to approximately 14% to 20% of all cancer deaths. Even modest weight loss can significantly reduce this risk. Exercise helps to maintain a healthy weight, thereby lowering the likelihood of cancer development.
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"Physical activity improves immunity, reduces insulin resistance, fat, inflammation, and estrogen – all factors that increase your risk of cancer recurrence and overall survival"
Taffie Lynn Butters,
Health Coach at The After Cancer
Sedentary life and cancer risk
In addition to the benefits of exercise, it's important to consider the risks associated with a sedentary lifestyle. Prolonged periods of sitting or inactivity can increase the risk of developing cancer, even in individuals who engage in regular exercise. This is because sitting for long periods is associated with metabolic changes, such as increased insulin levels and chronic inflammation, both of which are risk factors for cancer. A growing body of evidence suggests that reducing sitting time is as important as increasing physical activity when it comes to cancer prevention. Incorporating more movement into your daily routine, such as standing or walking breaks, can help mitigate these risks.
"Part of living an anticancer lifestyle includes exercise. Now exercise can be hard as a cancer survivor. You may be at a point in your journey where you just barely have the energy to get through the day to day, or take care of your personal needs, and exercise seems truly monumental. Or your life is filled and busy with work, family, to-do lists, and you don’t think you can fit it in the time for exercise. But what about a simple walk? Walking is exercise, right?"

Donna McMillan
Ovarian cancer survivor
How physical activity affects...
Tumor growth
Physical exercise has been shown to influence tumor growth and progression through various biological mechanisms. Exercise can induce metabolic changes in the body and within tumors, affecting cancer cell metabolism and potentially slowing tumor progression. These effects are thought to be mediated by several factors, including changes in hormone levels, improved immune function, and reduced inflammation.
Hormonal changes
Exercise helps regulate hormones like insulin, estrogen, and growth factors, which are involved in the development and progression of certain cancers. For example, regular physical activity lowers insulin levels, reducing the risk of insulin resistance, a condition linked to cancer development. Similarly, exercise can help lower circulating levels of estrogen, reducing the risk of hormone-dependent cancers such as breast and endometrial cancer.
Immune system enhanced
Regular exercise has been shown to enhance immune function, increasing the body’s ability to detect and destroy cancer cells. Exercise stimulates the production of natural killer cells, a type of white blood cell that plays a crucial role in the immune system’s ability to target and eliminate cancer cells. A study published in Cancer Immunology Research found that regular exercise increased the activity of these cells, leading to slower tumor growth in animal models.
Inflammation reduction
Chronic inflammation is a known risk factor for cancer. Exercise has anti-inflammatory effects, reducing the levels of inflammatory markers in the body. By lowering inflammation, exercise helps create a less favorable environment for cancer cells to grow and spread. A study published in the Journal of Clinical Oncology found that cancer patients who engaged in regular physical activity had lower levels of C-reactive protein (CRP), a marker of inflammation, compared to inactive patients.
Exercise oncology is an emerging field that focuses on the role of physical activity in cancer prevention, treatment, and recovery. This field is gaining recognition as more research demonstrates the profound impact of exercise on cancer outcomes.
Conclusion: exercise as a cornerstone of cancer care
Exercise is not just an optional addition to cancer care; it is a vital part of the prevention, treatment, and recovery process. The benefits of regular physical activity are numerous: from reducing the risk of developing certain cancers to improving treatment outcomes, enhancing recovery, and boosting the quality of life for cancer survivors. Through exercise, cancer patients can build physical strength, manage side effects such as fatigue and nausea, and reduce the risk of recurrence.
The role of exercise in cancer care extends beyond mere physical fitness. It has profound effects on hormonal balance, immune function, and inflammation reduction, all of which contribute to a healthier body and more effective treatment outcomes. Whether you're in treatment or post-recovery, regular activity tailored to your individual needs and abilities can help prevent complications, improve mental health, and support overall well-being.
It’s essential for cancer patients and survivors to work with healthcare professionals to develop a personalized exercise plan that suits their unique conditions, abilities, and goals. By integrating exercise into daily life, individuals can not only enhance their recovery but also build resilience and reclaim their sense of control over their health.
As research continues to support the importance of exercise in cancer care, the growing field of exercise oncology will continue to provide evidence for its critical role in improving patient outcomes. No matter where you are on your cancer journey, remember that taking small, consistent steps toward physical activity can have lasting benefits for both your body and mind.